Department of Biomechatronics Engineering, National Taiwan University
Tomatake Hall 403
Electrochemical sensing
Our laboratory is currently researching high-precision, stable, and cost-effective multi-ion sensing electrode array test samples and methods. This includes multi-ion sensing test samples, hardware integration systems, fixtures, and a mobile application (APP). The electrodes of the multi-ion sensing test sample can be produced using screen printing or semiconductor processes, with each individual sample containing multiple ion-selective electrode arrays and solid reference electrodes, allowing for miniaturization. The hardware component consists of a microprocessor, multiplexer, and Bluetooth transmission module. The mobile APP performs both calibration and measurement functions, allowing users to easily conduct simultaneous calibration and measurement of multiple ions through the user-friendly interface. The sensor can complete multi-ion measurements within a few minutes and has been validated through on-site testing, confirming its feasibility.
Apatsensing
DNA aptamers are artificially evolved biomolecules (ligands) that, akin to Darwinian evolution, are selected through a process of screening, elimination, and amplification from highly diverse nucleic acid gene pools. This selection process identifies DNA molecules capable of binding to specific targets. Our team has developed a unique aptamer screening technology that allows the rapid identification of aptamers with high affinity. These aptamers find applications in the development of biomedical sensors, drug therapies, disease diagnostics, and other technological advancements.
Microfluidic channel
The advantages of microfluidics lie in reducing the volume of experimental liquids and increasing the efficiency of bioanalysis through a high-throughput design. Our team is currently developing a microfluidic system that combines aptamers with electrochemical sensing. The goal is to achieve real-time concentration sensing signals with minimal amounts of the test solution flowing through the microchannels.