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 Miniaturized Impedimetric 
Bio-sensing Platforms 

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    Point-of-care needs are becoming more demanding with a growing number of innovative technologies and highly competitive markets. Bulky and costly instruments are being replaced by integrated bio-sensing platforms. Our group is dedicated to modeling interdigitated array (IDA) and other symmetric electrodes and applying them for impedimetric biosensing of proteins including tumor markers, which can further be commercialize for point-of-care needs. We have already derived an integral form of solution for the IDA diffusion impedance and an equivalent circuit model for electrochemical impedance spectroscopy (EIS) aptasensing. Currently, we are applying them for constructing a miniaturized IDA chip that can detect important tumor markers using EIS.

​Publications

  1. Lai, C.-Y., Weng, J.-H., Shih, W.-L., Chen, L.-C., Chou, C.-F., & Wei, P.-K. (2019). Diffusion impedance modeling for interdigitated array electrodes by conformal mapping and cylindrical finite length approximation. Electrochimica Acta, 320, 134629.
    doi: https://doi.org/10.1016/j.electacta.2019.134629​

  2. Lai, C.-Y., & Chen, L.-C. (2017). Detection of mucin1 with a microfluidic impedimetric aptasensor. Paper presented at the International Symposium on Smart-Sensing Medical Devices and 22nd Symposium of Association for Chemical Sensors in Taiwan, Tainan, Taiwan.

  3. Lai, C.-Y., & Chen, L.-C. (2017). The Study of an Impedimetric Microfluidic Chip Design for Mucin1 Aptasensing. Paper presented at the 64th TwIChE Annual Meeting, Taipei, Taiwan.

  4. Lai, C.-Y., & Chen, L.-C. (2018). EIS Detection of MUC1 with Two Symmetric Aptamer/Au Electrodes. Paper presented at the 22nd Topical Meeting of the International Society of Electrochemistry, Tokyo, Japan.

  5. Lai, C.-Y., Weng, J.-H., & Chen, L.-C. (2018). Real-time Impedimetric MUC1 Aptasensor using Microfluidic Symmetric Au Electrodes. Paper presented at the The Twenty Second International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2018), Kaohsiung, Taiwan.

  6. Lai, C.-Y., Weng, J.-H., Shih, W.-L., Chen, L.-C., Chou, C.-F., & Wei, P.-K. (2019). Diffusion Impedance Modeling for Interdigitated Array Electrodes by Conformal Mapping and Cylindrical Finite Length Approximation. Paper presented at the 11th International Symposia on Electrochemical Impedance Spectroscopy, Bordeaux, France.

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 Development and Application of 
Solid-contact Ion-Selective Array 

e-tongue_edited.jpg

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     Electronic tongue chips are developed with solid-contact taste sensors and ion-selective electrodes. Solid-contact sensor is an “all-solid-state” sensor which uses conductive polymers to replace the inner solution of conventional electrochemical sensors; therefore, having advantages of planarization and miniaturization.

     For application of classification of discrimination, the developed electronic tongue chips will be used to measure different analyte, then data will be analyzed with multivariate analysis.

​Publications

  1. Huang, S.-F. and L.-C. Chen (2019). Electronic Tongue Based on Solid-contact Ion-selective Electrode Array and its Application for Beverage Discrimination. 2019 CONFERENCE ON BIO-MECHATRONICS AND AGRICULTURAL MACHINERY ENGINEERING. Taichung, Taiwan.

  2. Huang, S. and L. Chen (2019). A smartphone sensing system for solid-contact Ion-selective electrodes. 2019 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN).

  3. Ho, L.-C., & Chen, L.-C. (2019). Development of a potentiometric PCO2 sensor chip based on the solid-state ion-selective electrodes. Paper presented at the 18th International Symposium of Olfaction and Electric Nose, Fukuoka, Japan.

  4. Wu, Y.-M., & Chen, L.-C. (2019). Fabrication of a PVC-based solid-state Ag/AgCl reference electrode. Paper presented at the 18th International Symposium of Olfaction and Electric Nose, Fukuoka, Japan.

  5. Wu, Y.-M., & Chen, L.-C. (2018). The influence of PVC/KCl membrane fabrication on the potential stability of a solid-state Ag/AgCl reference electrode. Paper presented at the 65th TwIChE Annual Meeting, Yunlin, Taiwan.

  6. Wu, Y.-M., & Chen, L.-C. (2018). Minimization of the potential drift for a solid-state Ag/AgCl reference electrode. Paper presented at the 2018 International Conference on Smart Sensors & 23rd Symposium of Association for Chemical Sensors in Taiwan, Taipei, Taiwan.

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 Development of 
Ion-Selective Microelectrode Probes 

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    We transplant the technique of solid-contact ion-selective electrodes in our lab onto the modification of microelectrodes. So far, a K+ solid-contact ion-selective microelectrode is fabricated and investigated as a probe to monitor the local K+ activity variation in scanning electrochemistry microscopy (SECM). The fabricated K+ SCISME has a theoretical sensitivity and the ability to detect the K+ insertion and extraction process of PB.

​Publications

  1. Wei-Li Shih, Yi-Min Wu, Lin-Chi Chen*, Cheng-Lan Lin*, "Monitoring the K+ insertion/extraction process of Prussian Blue with a Solid-contact Ion-selective Microelectrode", SECM 10th workshop (2019)

  2. Wei-Li Shih, Lin-Chi Chen*, Cheng-Lan Lin*, "A K+ Ion-selective Microelectrode Using a PEDOT Solid-Contact", 2019 International Conference on Smart Sensors

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