Intelligent Bio-Sensing Lab (IBS Lab)

Personal Information

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Name: Lin-Chi Chen (陳林祈) 

Title: Professor  

Affiliation: Department of Biomechatronics Engineering, 

National Taiwan University, Taipei 10617, Taiwan (ROC)

Tel: +886-2-3366-5335 

Email: chenlinchi@ntu.edu.tw

Scopus link: 62 referred papers with 1713 citations, h-index = 24

https://www.scopus.com/authid/detail.uri?authorId=7409439070

(in the fields of μ-SELEX and functional aptamers, biosensors and

biochips, nanochromics and nanocatalysts)

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Education (PhD of Chem. Eng./Electrochem., Post-Doc Trained in Biomed. Sci.)

2002.12 – 2005.07  Post-doc  Institute of Biomedical Sciences, Academia Sinica (Taiwan)

2001.11 – 2002.09  Post-doc  Dept. of Chemical Engineering, NTU / Nat’l Cheng-Kung University

2001.10 – 2001.10  Ph.D.      Dept. of Chemical Engineering, National Taiwan University (NTU)

1997.06– 1997.06   B.S.        Dept. of Chemical Engineering, National Taiwan University (NTU)

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Positions Held

Chair (2018.08 – present), Professor (2013.08 – present), Associate Professor (2009.08 – 2013.07), Assistant Professor (2005.08 – 2009.7) at Dept. of Biomechatronics Eng., Nat’l Taiwan University

 

Teaching Experiences & Subjects

Fundamental Courses: Physical Chemistry, Biochemistry, Bioprocess Engineering 

Applied Courses: Biomolecular Sensing Devices (Biosensors), Biochip Tech., Basic Biotechiques     

Advanced Courses: Nanoelectrochemistry, Biological Thermodynamics, Semiconductor Process

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Ongoing Research Projects

1. Microfludic impedimetric aptasensors for label-free cancer cell surface biomarker detection

2. Miniaturized electrochemcial sensor arrays for smartphone-based multiplex ion detection

3. Cell chips for anti-cancer drug delivery system assesment  

 

Honors and Awards

2018 – present NTU Special Talents Reward

2010 – 2013    Taiwan’s NSC Special Talents Reward

2012 – 2012    Mr. Wu Ta You Memorial Award of National Science Council, Taiwan 

​2009 – 2012    University Excellence in Teaching Awards, NTU

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Represent Publications in Aptamer and Biochip Research

1. J.-H. Weng, C.-Y. Lai, and L.-C. Chen*, Microfluidic amperometry with two symmetric Au microelectrodes under one-way and shuttle flow conditions. Electrochim. Acta 297, 118-128 (2019).

2. J.-H. Weng and L.-C. Chen*, Confocal epifluorescence sensor with an arc-shaped aperture for slide-based PCR quantification. Biosens. Bioelectron. 100, 71-78 (2018).

3. D.-K. Yang, C.-F. Chou, and L.-C. Chen*, Selection of aptamers for AMACR detection from DNA libraries with different primers. RSC Adv. 8, 19067-19074 (2018).

4. Y.-H. Lao, C.-W. Chi, S.M. Friedrich, K. Peck, T.-H. Wang, K.W. Leong*, and L.-C. Chen*, Signal-on protein detection via dye translocation between aptamer and quantum dot. ACS Appl. Mater. Interfaces. 8, 12048-12055 (2016).

5. S.-J. Wang, Y.-T. Hou, and L.-C. Chen*, A selective decoy-doxorubicin complex for targeted co-delivery, STAT3 probing and synergistic anti-cancer effect. Chem. Commun. 51, 13309-13312 (2015).

6. D.-K. Yang, C.-J. Kuo, and L.-C. Chen*, Synthetic multivalent DNAzymes for enhanced hydrogen peroxide catalysis and sensitive colorimetric glucose detection. Anal. Chim. Acta. 856, 96-102 (2015).

7. D.-K Yang, L.-C. Chen*, M.-Y. Lee, C.-H. Hsu, and C.-S. Chen, Selection of aptamers for fluorescent detection of alpha-methylacyl-CoA racemase by single-bead SELEX . Biosens. Bioelectron. 62, 106-112 (2014).

8. Y.-H. Lao, H.-Y. Chiang, D.-K. Yang, K. Peck, and L.-C. Chen*, Selection of aptamers targeting the sialic acid receptor of hemagglutinin by epitope-specific SELEX. Chem. Commun. 50, 8719-8722 (2014).

9. Wang, C.-S. Chen, and L.-C. Chen*, Prussian blue nanoparticles as nanocargoes for delivering DNA drugs to cancer cells. Sci. Tech. Adv. Mater. 14, 044405 (2013).

10. L.-C. Chen*, S.-C. Tzeng, and K. Peck, Aptamer microarray as a novel bioassay for protein-protein interaction discovery and analysis. Biosens. Bioelectron. 42, 248-255 (2013).

11. C.-W. Chi, Y.-H. Lao, Y.-S. Li, and L.-C. Chen*, A quantum dot-aptamer beacon using a DNA intercalating dye as the FRET reporter: application to label-free thrombin detection. Biosens. Bioelectron. 26, 3346-3352 (2011).

12. Y.-H. Lao, K. Peck, and L.-C. Chen*, Enhancement of aptamer microarray sensitivity through spacer optimization and avidity effect. Anal. Chem. 81, 1747-1754 (2009).

 

Book Chapter

1. L.-C. Chen*, J.-H. Weng, and P.-W. Lee, “State of the Art and Emerging Applications,” in Ch. 13 of “Aptamers for Analytical Applications: Affinity Acquisition and Method Design,” Y. Dong ed., Wiley (2019).

 

Patents

1. Aptamer for detection of alpha-methylacyl-CoA racemase and diagnostic kit thereof, US Pat.  9,518,301 (2016).

2. 3 aptamer Taiwan patents plus 15 other Taiwan patents.

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